Rabies

General Information

Rabies is a viral disease which occurs in more than 150 countries and territories. Dogs are the main source of human rabies deaths, contributing up to 99% of all rabies transmissions to humans.

Globally rabies causes an estimated cost of $8.6 billion per year.

Prevention is possible by vaccination, including post-exposure immunisation to be given as soon after the exposure as possible.

Transmission

Dogs are the main source of human rabies deaths, contributing up to 99% of all rabies transmissions to humans, according to the geographic area. Rabies spreads to people and animals via saliva, usually through bites, scratches or direct contact with mucosa.

Symptoms

After an incubation period of 3–8 weeks, non-specific symptoms appear, such as headache, fever and numbness of the skin around the site of the bite. A phase of seizures and eventually coma follows, which almost invariably leads to the patient’s death.

Epidemiology

Rabies causes around 59,000 deaths every year globally.

In the EU/EEA, no human rabies infections were reported between 2020–2022, however travel associated infections and infections in animals occurred occasionally.

Vaccines Pipeline

1
Vaccines in
the pipeline

TECHNOLOGY PLATFORMS

Whole-inactivated virus (1)

DEVELOPMENT PHASES

Phase III (1)

TRIAL POPULATION

Paediatric + Adults + Older Adults (1)​

Source:
Rabies. Available from: https://www.ecdc.europa.eu/en/rabies
WHO. Rabies. [Online].; 2024 [cited 2024 August]. Available from: https://www.who.int/news-room/fact-sheets/detail/rabies.
ECDC. The European Union One Health 2022 Zoonoses Report. 2023. Available from: https://www.ecdc.europa.eu/en/publications-data/european-union-one-health-2022-zoonoses-report.
[Accessed: August 2024]